Alby's Words

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Alexandria Dobkowski

Alexandria Dobkowski
Location
Austin, Texas, USA
Birthday
August 03
Bio
I was born and raised in Maine, where I attended a small private prep school and was taken into foster care at 16. Post legal majority, I spent time traveling the US, staying with friends and living out of my car. I settled in Memphis, Tennessee for several years, working for a book publisher. I am currently a writer, editor, and mother in Austin, Texas. Via Salon, I once debated with Camille Paglia over whether girls can rock.

MY RECENT POSTS

AUGUST 22, 2008 4:59PM

The Truth Behind Big Pharma

Rate: 10 Flag

There have been a number of posts/threads in the past few weeks about the election, the influence of lobbyists on politicians, and wholesale corporate greed (Tired of Evangelicals, Disaster Capitalists, What Do Lobbyists Do?, and my own Sexism+Capitalism) that I thought I would share some additional portion of my experience.

 

A few years ago, I was employed by a company that produced software used by the pharmaceutical industry and provided venture capital to clinical trial/research organizations. It was a very small company, and my job duties were necessarily diverse. Besides managing corporate communications and creating software manuals, I was sent to a number of conferences to research potential investment opportunities.

As a result, I basically got to hang around slobbering pharmaceutical executives, including one of their biggest conferences. I received an intensive education on sleazy Republican lobbyists, the Russian mafia, third world corruption, Medicare D and everything else scary and bad about the industry.

In 2005, I attended the Drug Information Association’s annual meeting in Washington, DC. To a certain degree it was fun. My job was to talk to people, and I enjoy learning what people have to say as much as it seems people like to talk to me. The fact that I represented a rich vein of American investment dollars did not hurt my popularity either. One of several reasons I am good at assessing important information is that my expressions do not give away my reactions, and I avoid passing judgment, which occasionally results in some people telling me more than they should.

 

Consider a group of clinical researchers I met among the many booths of the DIA. I was looking for a group that had access to a drug naïve European population for phase I, II and III trials. Why? The investors I represented already had partnered with a CTO in Asia, but their Asian population, although drug-naïve (meaning not already taking a bunch of meds like us ‘Mericans), was not sufficiently physiologically representative to the market as a whole. Asians are, in general, smaller, which affects how pharmaceuticals are processed by the body. At the time of the conference, European, especially Eastern European trials, were the new hotness.

I was in a booth for a Russian CTO, looking at their brochure. One of their representatives, a lead physician, approached me to ask if I had any questions. Before I could answer he spied my nametag.

“Ah, Dobkowski! You must be Polish!” Several other reps swarmed around me in excitement. I responded in jest, that being a Pole surrounded by Russians was instinctually discomfiting. The doctor laughed, and so did I. He was charming, warm, and clearly knowledgeable. When I told him why I was at DIA, his eyes brightened and he offered to give me whatever information I needed. I thanked him, and after taking a few notes, visited several more booths.

Later, when I had evaluated a number of options, the Russians were at the top of my list. I arranged an evening meeting between the doctor and my boss. The Russians have a similar manner of advancing drugs through to trial as we do, except where our pharmaceutical companies have lobbyists, the Russians have the mafia. I learned from the friendly doctor that he could exert pressure on the government to advance drugs to trials twice as fast as his competitors because he had a family member who held a high position within “The Organization”.

That he affiliated so nonchalantly with a criminal underworld surprised me, but not my boss, who seemed to think it was a good thing—for business. Later, the doctor confided in me that he had come to the US to escape that lifestyle and practice legitimate medicine. He seemed genuinely perturbed by some of the activities of his associates, but did not seem to think there was any other option. “I do good work,” he said, “but I could never do it without my connections.” He continued, “Besides, doing trials in Russia gives many people access to medications that they could otherwise never afford.” This is an excellent point, repeated by many other CROs I spoke with. But it was difficult not to ask why people could not afford life-saving and improving medicine.

 

At the end of the conference, the larger drug companies threw a number of parties. Compared to them, the company I worked for represented an insignificant amount of money, but without small investment companies, many drugs profitable to them would never come to market. I was invited to their parties, all of which were held in a different Smithsonian museum building. You heard correct: several drug companies each rented out an entire building. The one held at the National Air and Space Museum was said to be the largest, but one of the most interesting was the one held by Pharmanet at the then-brand new Museum of the American Indian.

It was disorienting: piles of smoked salmon, shrimp and lobster. Cascades of fruit so large they resembled Whole Foods displays. Multiple open bars serving premium liquor and champagne. A hokey, but talented band. Free tours of the museum. For a long time, I stood at the rail of the second level, overlooking the huge, semi-tipsy crowd. I walked slowly through the museum, appreciating the art and artifacts of a population so oppressed by poverty that it is almost as extinct as the Mastodons in the nearby Museum of Natural History. Did no one see the obscenity of this juxtaposition? I could not help but think of the people who funded this decadence: those who scrimp and save to peel off twenty or forty or a hundred dollars for the damn co-pay for their heart medicine. And that’s the lucky stiff with insurance. I felt like a spy, and perhaps, in writing this, I have become one.

I don’t think medicine should be given away, and like most people, I appreciate the science that goes into developing life-saving or improving drugs. But there is a vast spectrum of economic reward that precedes the life of Midas (especially when it seems the useless VPs talking about pipelines and cost-effectiveness are the ones reaping those rewards, not the scientists who exert grueling efforts in discovery and research).


While reading the literature piled in drifts on the conference floor, one of the loudest refrains I kept hearing was one of an image problem: Michael Pucci of GlaxoSmithKline was quoted by the FDA’s Drug Safety Advisor as complaining about the public that “they don’t view us as human.” Because using divisive terminology like “us” and “they” really helps. He later goes on to say that a message that can overcome that view is that the industry “cares”. The quotes are his. Picture him making them with his fingers, the prick.

Do I have advice for the pharmaceutical industry? You bet I do: if you, as a pharmaceutical company want to change public perception, you will only do so through genuine action, even if it means a cut in profits. Charge for drugs, but stop charging so damn much for drugs. Do more for sick people. Don’t, for god’s sake, drag your feet on AIDS research and on providing meds to populations who can’t afford them. Do pay your scientists better. Don’t push drugs on doctors, do make sure drugs are safe, or at least give adequate warnings and risk assessment.

Drug companies can develop the cure for cancer, AIDS, and the common cold, but as long as the perception is that the primary motivation is profit, profit, profit—nothing “they” sell is or should be viewed with anything but suspicion, especially given their track record so far.

Still, these points are so damn obvious to anyone who is human that I can’t help but think the doubts behind Big Pharma’s humanity have merit, and nothing I have heard on many pharmaceutical investment calls since has convinced me otherwise.

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It is worrisome, isn't it. I did learn something, however, that I had not previously entertained. That the industry is aware of how they are perceived.

It is kind of like Ms. Universe posturing that she feels bad that the "ugly" girls are frowning in the face of her beauty. After all she "cares" about the world enough to be its ambassador for a year, can't they see that and be HAPPY about it?
You say pharmaceutical companies can develop the cure for cancer, AIDS, and the common cold. I say bullshit. Do you wear aluminum foil on your head?
LaLu: yes, and the idea that you can change your public image without having to actually do something seems to be a cross-industry trend

Mr. Bart: you are correct. I should made the hypothetical nature of the statement more obvious by using the clunkier construction "could develop". I thought that reading the remainder of the sentence would have made it easy for you to understand its meaning.

I try to reserve my tinfoil hat for special occasions.
A hypothetical statement does not start by saying that an entity can do anything. You make it sound like fact, not hypothesis. Why don't you conjure up some cures, how about one for Parkinson's disease for my father who hallucinates every day. You sound like a smug little girl out of touch with reality. We humans are limited in our ability to solve much of anything. Blaming others and conspiracy theories don't help.
You present this post as if you have something new to add. Pharmaceuticals are a business, a very big business and that is how it is. I'm not exactly clear what your gripe is here.

The electronics industry generates billions in unrecoverable and potentially harmful waste every year. E-waste for eons to come, and they lobby, and they spend billions every years on their issues .

Now, had your post focussed on the ethical issues of recruiting these "naive" populations for trials of drugs without informed comnent; without the basic safety and efficacy studies; without the oversight of FDA to try to ensure basic safety - you might have had a "hook". Understand that YOUR COMPANY'S practices lead to people being paid to inject or swallow drugs of totally unknown certainty - MOST of which will NOT be accepted by FDA as legitimate clinical studies - then you might have a sympathetic ear.

As it stands, you and your company need to hire an ethical, experienced , regulatory consultant to direct your efforts. Emphasis on Ethical.

Feel free to email me.
Kind Mr. Bart, if I seem smug to you, I assure you it is the opposite of my intention. Our perspectives are similar in that I strongly feel that, pharmaceutical companies can and should do more for cancer, Parkinson's, and many other diseases.

I never claimed conspiracy; the fact that drug companies pour money into what they think will profit and not what won't, has never been hidden. The reluctance of a few companies to provide AIDS drugs at a reduced price to developing countries made front-page news. Eventually the company capitulated, and it certainly did not drive them out of business.

Human limitation does not mean we must be happy with what drug companies currently give us.
AAAARagghh - can one not correct one's errors?

"Informed comment" is, of course, "informed consent"
I read the sentence in question as "even if the drug companies developed a cure for cancer, AIDS, etc, it wouldn't matter as long as it seems that they are only in it to rake in the profits." And I can't disagree with that. I know that there are people in the pharmaceutical industry who are genuinely interested in helping others. But there are plenty who are only concerned with how much they can charge.
Kelly, if you are unsure what my gripe is, I admit that I am even more unclear as to what yours is. That I did not write about a different facet of the pharmaceutical business? That I am critical of corporate attitudes towards the people they depend on for profits?

I am also confused by your criticism of clinical trials. Business is business, and that's how it is, right? Didn't you say that? Pharmaceutical companies seek drug testing at rates as inexpensive as possible. There was and is no illegality about using foreign CTOs per se. Many companies do.

Regarding the company I once worked for, the software that it produced made trial data secure, minimizing corruption.

In this context drug-naive does not mean stupid. It means not taking other drugs. As the doctor in my story mentioned, many people in other countries seek out these trials, just as cancer patients (or others) do here. Yes, there are some unethical CTOs, both here and overseas. But most employ a supervisory committee, including an ethics officer to monitor the trials.
Ms. Dobkowski, what I object to is you ignorance of what we are capable of treating. Oral or IM medications are probably not the way we will cure Parkinson's Disease or Scleroderma. Instead, we will likely attack it at the genetic level or some other method. Pharmaceuticals are rather crude attempts to cure most illness and again I will say there aren't that many new drugs or vaccines out there because we humans, despite all the money and all the minds haven't figured out how to cure most illness. We just can't fucking do it, get it? All the King's horses and all the King's men, couldn't put Humpty together again! Maybe in two hundred years.
Um, wow. I'm not sure what just happened here with the hostile comments, but I appreciated your post and perspective, as usual.
Thanks as always JP.

The abrasiveness doesn't bother me-- I'm just happy that folks show even a marginal interest in the topic and am always happy to try to clarify points that may be unclear.

Novartis, GlaxoSmithKline, and other major drug companies already pursue genetic research, either themselves or with partners.
I'm also surprised at the hostile responses, but I am very impressed with your gracious attempts to deal with them Alexandria. It speaks well of you.

Black Bart, There is not a pharmacological magic bullet that can cure cancer, AIDS, or many other serious diseases, granted, but there have been significant improvements in the treatments for many diseases. I am currently taking a drug for breast cancer that has made a real difference in survival rates for women like me. No, drugs can't cure everything, but they do treat and cure a lot of serious and life-threatening illnesses.

I'm also very confused about Kellylark's post. Are you asking suggesting Alexandria's former company should hire you?
Liked your post. Also noticed folks were being mean for no apparent reason.
I am simply suggesting that Alexandria's post is, in and of iteslf, naive. WOW. big story. Pharmaceuticals are big business.

She is in the same purview with nasty big computer-business, yet doesn't see it. Pharmaceuticals expoikt, yet computers don't. Give me a break.

If she REALLY knew what she was talking about, then the heinousous would not be in dispute. She is talking about unscrupulous drug companies seeking overseas guinea pigs desparate for funds that agree to risk life and limb without informed consent for very real survival dollars.

She is schilling for a company looking for "naive" countries that will allow their citizens to become Phase I and II guinea pigs in unapproved trials.

She is. in effect, bemoaning the fact that there are terribly unscrupulous people offfering up naive citizens for drug trials, and participtatig wholly in the deception.

Is that more clear?
"Is that more clear?"

Not really. I'm sorry, but I really don't see how any of what I wrote could be considered "shilling". I worked for a software/VC company for a couple years. I left as soon as I found something better. My post was about an experience I had at that job. I think posting this, my experience as related to the pharmaceutical industry, is the opposite of "deception".

If anyone, in this country or another, is not adequately informed before they participate in a clinical trial, I disagree strongly with that. I believe I said something to that effect in my post.

If you are to speak of heinousness, I am curious if you ever wonder why big companies behave the way they do--also the subject of my post and other posts.

And just to clarify further, I don't believe "news" is one of my tags here.
I stand corrected and try not to get too frustrated and use bad language. My concern is that people actually believe we are close to curing most disease and entities are holding back the cure. People, science is a long way from finding the fountain of life. I wish it weren't so but we have such a long way to go. Just because companies, universities and the government are doing genetic research doesn't mean we know how cure disease with genetic manipulation. It's a long way off. Nobody is holding anything back. Most of what pharmaceutical companies come up with are clones of drugs discovered by other companies. And the discoveries are slowing down.
I think you need to re-read what Alexandria posted (and later commented on), because she clearly said that "naive" doesn't mean what you seem to think it does when referencing clinical trials. It only means that these folks haven't been subjected to lots of drugs (as we have here in the US). And where are you getting that the drug companies are not getting informed consent?

The point was (at least in my perception) that drug companies are able to offer drugs at lower cost, but they don't until they are bullied into it. Further, the execs are paid more than the scientists.

Lastly, Alexandria doesn't work for this company anymore.
Alexandria: I thought this was a really good post. You weren't passing judgment as much as you were offering a very subjective (e.g. personal) perspective of an industry based on your experience working within it. Having been to events that rent out museum space and put out lavish spreads, I'm able to relate to the disparity between opulence and the society those who have it serve.

In all, your title may have been misleading. But, then again, titles usually are. You didn't expose the truth as much as you did a truth, and it certainly was a lovely truth which exposed facets I knew of but not in dreamy detail.

Pah. Keep it up.
The Russian Mafia is a far bigger threat to this country than Al Qaeda is. In fact, the threat of the Russian Mafia is global. They make the Cosa Nostra look, well, Italian.
Great post, I used to wait tables at a high-end steak restaurant and we were simultaneously thrilled and sickened at/by the money we made from them

Kelly, this is not the first time I've seen you release your inner troll. That's not the way we do things around here and I'd like you to present your opinions in a civilized manner, please.

Back to pharma, I'd really like to see some less toxic treatments for autoimmune diseases. A cure would be better.
"Drug companies can develop the cure for cancer, AIDS, and the common cold, but as long as the perception is that the primary motivation is profit, profit, profit—nothing “they” sell is or should be viewed with anything but suspicion, especially given their track record so far." Dobrowski

No profit, no drug companies. Who would invest in research if the pay off wasn't there? Would you? Suspect all you want but there are no regulations that state what types of drugs have to be developed. If there were they might kill the industry. Why not let the government develop new drugs instead of new weapons? Maybe that's an option but we still have lots to learn before we can cure cancer. We don't even understand the long term effects of many industrial chemicals and pesticides.
I said, "as long as the perception is that the primary motivation is profit, profit, profit—nothing “they” sell is or should be viewed with anything but suspicion..."

Mr. Bart said, "No profit, no drug companies. Who would invest in research if the pay off wasn't there?"

This is an erroneous assumption I see often: that not having profit as a primary motivation means that no profit is possible, or that there is no ability to include a real concern for humanity alongside profit as a motivation in a business.

As just one example, there are 675 companies in the United States who belong to 1% For the Planet.

The Pharma exec I quoted wanted some solution to the industry's image problem--without having to actually do much more than make a commercial. The point that I made was that they could still be profitable companies while respecting the source for their profits (us), but that their image will not change unless that respect is genuine.
Alexandria - I enjoyed your post and thought you made a lot of good points. The image of the cornucopia of food (and beverage, I'm sure) at the Pharma table really sticks in my mind.

The government has put the brakes on Pharmaceutical reps wining and dining doctors. I suppose a bit of it still goes on, but in a significantly decreased manner. I feel sort of sad about the lack of interaction with the reps because it was a great way to learn about new medications, although the dinners were ridiculously over the top.

I'm not sure what caused the stir in BlackBart and KellyLark. I suppose it's good that you're being read and I think you handled the criticism (which was NOT constructive, by the way, guys) very well.

I regret that this wasn't an "editor's pick" because I would have liked more people to see it. Keep writing here.