Alicia PhD

Alicia PhD
Location
New Hampshire, United States
Birthday
September 08
Bio
Alicia has a PhD in Experimental Pathology and, after having worked in a genetics lab for her dissertation, now edits scientific manuscripts full-time from the comfort of the White Mountains. Alicia is also a writer, contributing health commentary and articles on disease and anatomy to many online publishers. She upkeeps a number of blogs devoted to her interests in public health and science.

MY RECENT POSTS

OCTOBER 27, 2010 2:10PM

We really are all unique

Rate: 3 Flag

DN Mutations May Not Be Repaired

Traditionally, the term species means that one group of critters is different from another group of critters. In the genomic age, it refers to genetic differences - though chimps and humans have 96-99% similarity when comparing the genomes - there is just something that creates those differences we see. 

Similarly, humans were thought to be identical, with some higher power bestowing differences ("that's how God made me"), but now we understand that slight genetic mutations make each individual human different from another, and that together these genetics make up the species - which also shows how easily evolution could branch out to form a new population.

A project pursued to further understand these differences was the 1000 Genomes Project. And guess what...we're all very very different.

 The pilot phase of the project found 15 million gene variants, up to 1% of all human genes, among the 1000 human genomes surveyed (using both low and high accuracy sequencing). Some of these variants make no changes in how a person is put together, others do (like hypertension, diabetes, autoimmune disease, addiction, metabolic disorders, etc), but the amount of variation they found within a small group of the population from the same species is somewhat surprising. It may also explain why finding the genetic mutations associated with disease has been so hit and miss- there are just so many and may not be the same in everyone.

The next step for the project is 2500 genomes.  I'm not lying when I say I am intrigued.

Image: DNA repair, point mutations and genetic variability can occur if DNA breaks or aberrant replication are not repaired

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Comments

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Excellent, hopefully it will soon become acceptable for us to not to think, act and appear identical. Maybe next someone will discover that equal and identical are not exactly the same word. Maybe even figure out what the mutations are. I shall resume hope for us.

You have gone a long way in reassuring me that we are indeed making some progress in this millennium. Spinning backwards seems counter productive. Great post, thank you.
terrific post, short on prose and long on intelligence.

...reminds me of "Life of Brian", I must say, when he tells the crowd "You're all individuals!" and they drone back "We're. all. individuals,"
Wow! This is fascinating. I hope you post more about this.