Scruffus

Scruffus
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OCTOBER 27, 2008 10:13PM

The Mad Scientist in Your Neighborhood

Rate: 4 Flag

It's always exciting when you read about someone you know in the news. A friend from college made the local news over the weekend. 

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The story seemed a bit overblown and sensationalized, complete with pictures of the Haz-Mat team in their spiffy yellow suits. The reporter lists toluene, dimethylamine, and "caesium hydroxide" as chemicals seized from my classmate's apartment and it was then insinuated that these chemicals could be part of a "makeshift, low-quality methamphetamine operation". Now, I was in class with Billy for many years and his lab skills were top notch. He was one of the more dependable students in lab, held a job in industry outside of school, and was never one who had to be watched over. Billy was a student who had an innate ability to work well in a laboratory setting. It just didn't ring true that he would be part of any low-quality operation, especially when it came to chemistry. 

The overreaction of the police department is understandable considering methamphetamine use has exploded over the past few years. But domestic makeshift meth laboratories have decreased since the passage of the 2006 Patriot Act. Legislation contained in the 2006 Patriot Act limited the sale and storage of over the counter medicines containing psuedoephedrine or ephedrine. Since then, it has been more difficult for domestic meth producers to obtain the preferred ingredient for efficient synthesis of methamphetamine. The chemistry is simple in theory, but dangerous in application. The gap in domestic production has been filled by Mexican drug trafficking organizations, who are more than happy to provide a drug that is so cheap and quick to produce and which is in high demand in much of the country. Now 85% of meth comes from super-labs in California and Mexico.

Pseudoephedrine is remarkably close in structure to methamphetamine.

180px-Methamphetaminemethamphetamine

175px-Pseudoephedrinepseudoephedrine 

 

Using pseudoephedrine as a precursor is easy because hydrogenation of the hydroxyl group (the OH) is all that is required to change pseudoephedrine to methamphetamine. Iodine and red phosphorous are required to assist in the hydrogenation. The danger comes from the evolution of phosphine gas, PH3, which is spontaneously flammable in air under certain conditions. Another method of producing methamphetamine is by a Birch reduction using lithium extracted from rechargable batteries and anhydrous ammonia. This method is not much safer since anhydrous ammonia may boil explosively when the reagents are added.

The chemicals allegedly found in Billy's apartment were toluene (a common industrial solvent, found in things like inks, perfumes, dyes, paints, and lacquers), dimethylamine (a gas at room temperature, used in the manufacture of detergent soaps or as an attractant for boll weevils), and cesium hydroxide (corrosive, but used as a catalyst in polymerization reactions of cyclic siloxanes). None of the listed chemicals sound any more dangerous than things any one of us could purchase at a hardware store. I don't know what Billy was doing with these chemicals, but manufacturing methamphetamine seems highly unlikely.

It is known that drug use is a great problem in society. The use and manufacture of methamphetamine is especially troublesome. The side effects to the users are unpleasant.

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The medical and dental costs to treat meth addicts are high. And cleanup of just one makeshift lab can cost law enforcement around $2000 or more. Meth lab explosions present a danger to the amateur drug makers and their neighbors.

 

 Despite the 2006 Patriot Act, methamphetamine continues to spread and instead of being a mom-and-pop production, it has now become an underground industry, a source of income to fuel criminal organizations. Drug policy in this country has failed to prevent the spread of drugs and has led to the incarceration and leveling of criminal charges against otherwise law-abiding people. Drug laws are filling our prisons, wasting our money and doing little to stop the use of illegal drugs.  

Billy seems to have been caught up in the hysterics associated with our drug laws. I seriously doubt he was trying to synthesize any drugs. I still had his cell number from when we were in school so I sent him a text to make sure I wasn't going to have to bring him cookies in prison. He said he was okay and the whole thing was blown out of proportion. The newspaper did not accurately report the chemicals he actually had which helped to sensationalize the story. Much of what he had is commonly available at hardware stores. He seemed annoyed at the inconvenience and as I suspected, he found the most upsetting thing to be that the paper reported he was running a "low-quality" operation. "If I was doing illegal chemistry, it would be done well, dammit!" 

Drug arrests are not only inconvenient, but life destroying. It can hinder one's ability to become employed and affects one's ability to qualify for student loans. In the event someone with a drug record wants to improve his or her life, the arrest record is a ball and chain that must be carried along with them on their uphill journey to a normal life. I hope my friend will be alright and not face serious charges. 

I also hope that the next administration rethinks drug policy in this country. Few people see drug offenses as crimes requiring incarceration. Addiction should never be treated as a crime in the same way that assault is treated as a crime. The legalization of drugs would eliminate the black market that persists no matter how many billions of dollars are thrown into the War on Drugs. We will never see any kind of victory without more sensible policy. 

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Chemists don't let other chemists get worked over by the news.
Scruffus,

Most high-quality, bulk methamphetamine is made using what is known as push-pull hydrogenation, utilizing H2 under pressure. (not a Parr-Type reaction, but low pressure gas,) Certainly not Mom and Pop stuff there. The Hydriotic Acid reaction is unsafe because as you point out, Phosphine Gas can be released if the reaction gets too hot. The real danger here is that Phosphine Gas is deadly poisonous: one good lung full and you're dead, in very short order. The Birch produces a very pure product, and very quickly, hence its popularity with those who manufacture. Again, the biggest danger here is inhalation of the ammonia: one lung full will scorch your alveoli, they will fill with water, and you will drown in your own fluids. You're spot-on when it comes to meth production in this country. Even at it's highest point, domestic production amounted to a eye-dropper full when compared to the Mexican super-labs. The government, more specifically the DEA, has gone totally feral on this subject, and anyone with a couple of boxes of Sudafed in their house, along with a bottle of drain cleaner, a some kitchen matches, and maybe some kerosene lying about could be nailed with "intent to manufacture". It is insane and way overboard. I do alternative fuels research in my spare time and getting reagent-grade chemmies is a pain in the ass, due to the DEAs infamous "precursor watch list", which, if it gets any longer, will surely include water as well. These people have destroyed independent, private chemical research, and it is a pity.

I am sorry to hear about your friend, and judging from the chemicals you listed, there is nothing that he possessed that could be used to manufacture anything illicit. Just knee-jerk overreaction by the authorities, hell-bent on getting another slice of government grant money to prolong the idiotic and ultimately futile "War on Drugs". I hope that some sanity will prevail in the near future regarding this poorly-conceived and equally foolish "war".. Maybe with the current financial crisis, the budget-trimming will extend to the DEA, and they will be forced to downsize, and be absorbed into another agency like ATF. Their reign of terror is typical of a rogue agency which effectively answers to no one, and unfortunately this madness extends to local law enforcement agencies as well.

The toll in prison is equally deplorable. Nearly 60% of all current inmates in this country are in for non-violent personal quantity convictions, and that is inexcusable. They do not belong in prison, they belong in rehab. The biggest culprit here: 'Federal Minimum Sentencing Guidelines', which tie the judges hands. They are forced by Federal Law to hand out these Draconian prison terms, and have no recourse. These so-called "Guidelines' should be repealed immediately.

A superlative post.

Joe
Wow, Joe Blow, excellent comment! Yeah, I saw the set-ups used by industrial scale operations and it is clearly not something used in someone's basement. All Billy had was toluene, HCl, and some ammonium hydroxide. If the ammonium hydroxide was the concentrated, there was no way he was opening it outside of a hood anyway. It will clean your sinuses for sure. 6N of that stuff is still enough to be irritating. He also had some liquid scintillation vials, which I'm sure the cops assumed he was using to store or distribute drugs.

It is a shame that curious and intelligent people cannot properly conduct home research.

Thanks again for your thorough and well-thought out comment. I think you're right that a lot of the hysteria comes from the government continuing to scare people about drug use and manufacture.
Scruff-Meister,

The only weapon they've ever had is really just the promulgation of fear. All the "research" they've commissioned to demonize most recreational substances is faulty, is easily disproved, and wouldn't hold water if reviewed by an independent board of analytical chemists, but it's still being used by the gov't. to intimidate the populace. The earliest of these Gov't sponsored programs was the "Reefer Madness" movies of the 30's...hilariously inaccurate, but fun to watch.

The latest Gov't.-sponsored paranoia is the chemical watch list for items used to make explosives. This list includes stuff like nitromethane, ammonium nitrate, acetone, hydrogen peroxide, nitric acid, and so on. Like anyone in their right mind is really going to attempt to make acetone-peroxide-based explosives in their basement. The stuff is almost as volatile as nitroglycerin, and you'd probably blow yourself up in the attempt. The watch list for nitromethane is equally ludicrous. I use this chemical in my work. It's true that you can make Astrolite G, (a high-explosive using nitromethane and ammonium nitrate, but then you need a Class 3 cap to set it off, and they can't be had anywhere, unless you have a mountain of federal paperwork), but the process is very dangerous, and requires careful attention to keeping the stuff below a certain temperature while its reacting, and if not: "Poof"...you're worm-food.

The Gov't. thinking on this particular arena of prohibition is that by limiting access to these substances, that they will be able to prevent anyone from constructing an explosive device. Bullshit. If someone is motivated enough, all the restrictions in the world are not going to hinder them. You can construct an air-fuel explosive using nothing much more than high-octane racing gasoline, a time-delay ignition device, and a bottle of pressurized oxygen. For extra zip, throw in the contents of 4 or 5 cans of starting fluid, and you have a device that will surpass dynamite in force. This fear-mongering attitude is part-and-parcel of the Republican paranoia, along with sexism, homophobia, stem-cell research, etc., etc. These people are mentally unbalanced and severely misguided, and unfortunately, their disease has affected the entire country by virtue of their insane lawmaking. The Patriot Act, (I love the way they conceal a piece of horrendous legislation in a clever flag-draped package, don't you?), was nothing more than an Act to shred the Bill of Rights further, and once again, fear was used to gt it passed...and the country fell for it. I hope Obama takes his "scalpel" to this agency as well. It has done absolutely nothing to make us safer than we were before 9/11.

'preciate the nod on my reply, too!
I struggle with the legalization of illegal drugs. I believe that you will never rid the world of addiction, but if you make the current round of drugs legal will there be an incentive to come up with another group of illegal drugs. For those that look for the bigger and better high this is sort of inevitable. My other view is that maybe if we legalize it then benefits for treatment would become as widely available as incarceration. But then I realize that this may be a naive position. What do you think?
Actually, making the original group of drugs that were in vogue during the 60's illegal, led to the use of more exotic ones, as a substitute for the originals. That is one of the reasons I believe that kids are sniffing gasoline, nail polish, and raiding Mom and Dads medicine cabinet for pharmaceuticals..they can't get anything decent off the street, so they turn to alternatives like Robitussin, paint thinner, computer keyboard aerosol de-dusters, and the like. The drug prohibition we have in this country actually drives users to even more exotic, (and generally more toxic and deadly), chemicals as a way of altering their concious state. It's basic human nature to experiment with mind-altering substances, and the human brain is hard-wired for pleasure. In short, we can't help ourselves, and I say; if we are predisposed to this kind of behavior, (and we are!), let's try to make it as safe as we can.
Velina, I think legalizing drugs has the positive benefits of eliminating a black market that benefits criminal organizations, prevents sending people to prison for an issue requiring medical treatment not incarceration, and would subject drugs to standards of quality and purity. Anyone with a casual street habit must guess at where the drugs came from, what additives have been put in and what is the potency. It's like Russian roulette with chemicals. I think drug use continues, whether or not it is legal, and the criminalization has only led to our government wasting tons of money to enforce the laws, prosecute the offenders, and incarcerate them for lengthy sentences. The ones benefitting from drugs being illegal are the gangs and suppliers who are making a profit from the inflated prices. What we need is legalization coupled with a massive public education campaign akin to what was done for littering and smoking. It is a hard decision because no one wants to see a human being destroy their lives through drug abuse, but laws against drugs have not had the desired effect. Much of turning to new drugs has to do with economics. Crack is cheaper than cocaine. Legalization would bring prices down tremendously while increasing safety to the user because of regulated purity. Hopefully, more people would be inclined to seek treatment. Addiction is also a problem with legal pharmaceuticals. The pharmaceutical addict is not a criminal (as long as the prescription is valid) but the street drug addict is considered a criminal. It just doesn't add up. An addict is an addict and needs treatment, not jail. We also need to think about why such people feel the need to be high, to find the root cause of widespread addiction
Thank you so much for your thoughtful comment.
Thanks again, Joe, for your positive and insightful contributions to the conversation. By the way, that's pretty cool that you do alternative fuels research. I want to set up something in my garage to work on something similar.

Methamphetamine has always been fascinating to me. When I read about my friend getting arrested for allegedly running a meth lab, I had to write this post because he was being trapped by the hysteria and it happens to others. For the people who really do make drugs at home, I often wonder why they aren't in school getting a PhD or something. If someone has such an aptitude for chemistry, it seems a shame that he or she gets stuck in a trailer park cooking up drugs in closets.
Scruffus,

Nearly anyone who had college-level O-Chem cranked out some kind of illicit substance during their time, courtesy of the colleges' chem locker...it was almost a rite of passage to do so, and I'll bet you'll get a nod or wink from a 60s or 70s vintage Chem grad on that score.
Methamphetamine is a stupid-simple item to make. Hell, I've even read synths starting with bitter almond oil, (benzaldehyde), to make it. (Imagine the DEA raiding Betty Crockers place...no more cookies for you, lady!) It is, however, a compound that is truly nasty, and right up there with the opioids in terms of destructive capabilities, invented by no less than your friends at Bayer A.G., (Yeah, the aspirin guys), who also invented heroin, and Zyklon B, Hitlers favorite nightey-night compound for the concentration camps during WWII. It should be outlaw, but the reason it has caught on? Cocaine is too expensive. Meth is dirt cheap, and the effects last for days, not hours.

I've tuned into some of the web sites that feature round-table discussions on the subject of drug manufacture over the years, including the infamous "Hive"and 'Science Madness'..What I find remarkable is how creative these people are when it comes to alternative methods of producing their favorite drug of choice. These people are not ignorant hillbillies fooling around with mason jars full of iodine and red phos either. Judging from what I read, a lot of them were post-grad chemists and knew their shit. Trailer trash don't know doo-doo about a Ritter or Claisen reaction, or organo-metallic reactions, but these 'underground' types were totally up on their methodology. I think it's partly the mental challenge of pulling it off, coupled with the fact that they like getting high..a perfect storm. You can bet that a lot of them are in the chemistry trade too...they simply know too much to be 'Backyard Bar-B-Que' types...and who said American ingenuity was dead? These maniacs are living proof that the spirit still lives. I won't advocate their predeliction for this type of experimentation, but you have to admit one thing: at least they know what went into the capsule they swallowed!
Joe,

Ha ha, yeah, I won't even go into what went on where I went to school. We had some real inventive characters when it came to cooking up stuff in the lab. PCP is another nasty drug that's not too hard to synth given what's in your average chem stockroom. Our school was small, so we were given free reign in the lab to do "research" for hours on end. The good old days.

You theoretically could go from the methyl on the toluene to methamphetamine but like you said, it's easier to go with a carboxyl group like on an aldehyde. Carboxyls are easier to attack. Billy didn't have the ingredients it would take to go from a methyl to an amine. People have to be careful of side reactions, too, and different synths can require cleanup, adding to the cost of the process. Chemistry is all about fast and cheap.

It is fascinating how people will put so much effort and pride into some of these home labs. I like reading stories about people who run home stills. These are usually very clever folks. There was a guy running a good moonshine operation out of the Dismal Swamp for a while until he got caught. But that's another post.

You've made some great points and I'm thoroughly tickled to find another science geek.
Umbrellakinesis, thanks for your comment and yay! another science person! Your story about your neighbors sounds scary. I'd sleep with a bat at night if I lived near people that did that. I heard about meth addicts drinking constantly, preferably sugary drinks, which contribute to meth mouth. From all the grinding, sugar and dry mouth, their teeth are eaten away. It's fairly unattractive. The East Coast doesn't have the same meth problems as the West Coast and the middle of the country. Not yet, anyway. It's such a multilayered problem. Medically, many of these people are uninsured. If they sustain burns from a lab explosion or meth mouth, they incur great costs to the hospital system. The addiction itself needs treatment. And like you illustrated so vividly, they can be a hazard and menace to the community. I think the public should be aware of how pervasive something like this is and work to craft a better way of dealing with these problems.

Thanks for your lively contribution to the discussion.
Yeah, now if I could just find some kind of nucleophilic carbon compound that would donate carbon atoms to CO2-infused H2O in an electrically-charged cell, producing a secondary alcohol, I'd put Exxon out of business.
I tried for a while to follow this conversation, but I wasn't able to stick with it for only a short while. What I wanted to comment on was your new avatar. You look lovely! Nice job.
Thanks, Susan. That's sweet of you to comment on it. I thought it would be cool to be me for a couple of days and not my little "Scruffus" bird.
Scruffus;
I've got too much time & money invested in all the gadgetry to quit now..."In for a Penny, in for a Pound"...besides, it would take too much work to dismantle all this apparatus without some kind of payoff. Ya never know, I might just fall into the toilet and come out with a new suit and a brass band! I'll let you know from time to time how my Frankenstein Monster is progressing.

Joe.