Xylocopa

Patrick Hahn

Patrick Hahn
Location
Addis Ababa, Ethiopia
Bio
I used to wash trucks for a living.

Patrick Hahn's Links

The Medical-Industrial Complex
The War On Drugs
The Nutritional-Industrial Complex
Personal reminiscences
Scientific articles
Personal essays
Books of interest
MARCH 4, 2009 5:25PM

A tepid defense of animal experimentation

Rate: 2 Flag

lab rat 

(N.B.: My thoughts on these matters have been influenced greatly by C.S. Lewis’s essay, “On Vivisection.”

I used to think the animal-rights advocates were the biggest idiots on God’s green earth. How, I used to wonder, can anybody be against “saving lives?” But now I realize it’s not that simple.

Most people, myself included would assign a greater value to the life of a human being than that of a rat or a dog. But, as Noam Chomsky said, Whoever defines the question wins the argument. It’s an open question as to just how much the pharmaceutical industry is committed to “saving lives.”

This book by Nortin M. Hadler, M.D., details all the tricks the pharmaceutical companies use to get their pills and potions approved on the basis of meager effects which may be statistically significant without being clinically significant. And, since the possibility of iatrogenic illness always exists, anything they do that doesn’t have clear beneficial effects should always be considered harmful. Is it really worth it, to make all these animals suffer, just so the pharmaceutical industry can make even more billions foisting more useless and/or harmful “medicines” on the public?

The animal rights activists like to argue that results on animals do not tell you anything about how a given medicine or procedure will work on people. I disagree. Consider the astonishing story of the artificial heart, as detailed in this book by medical anthropologists Renee Fox and Judith P. Swazey. The designers tested that thing in sheep and calves for years, and every time they implanted it in an animal subject, the poor thing developed massive infections and suffered terribly and died soon after. So they tried it out in people, and lo and behold, they developed massive infections and suffered terribly and died soon after. I can’t help wondering what was the point of testing it in animals, if they were determined to use it in people, regardless of how dismal the animal results were.

By the way, the mendacity of the developers of the artificial heart didn’t end there. Robert Jarvik, the developer of the artificial heart, who has never in his life been licensed to practice medicine anywhere on the planet, used to give press conferences dressed in surgical scrubs. Why didn’t he dress up as a cowboy, or a fireman? Would have made just as much sense.

Dr. Robert Jarvik 

And if you were wondering what was the medical or scientific value of all this, the answer is: none at all. Dr. William Devries, the surgeon who implanted the Jarvik-7 artificial heart into the hapless Dr. Barney Clark, later moved his base of operations from the University of Utah to Humana Hospital in Kentucky. When the University of Utah IRB asked to see his files, he claimed he lost them! Either he was lying or he was telling the truth, and frankly, I’m not even sure which is more appalling.

Still, I believe that a cogent case for animal experimentation could be made, provided such research was restricted to that which actually had the potential to save human lives and/or improve their quality (and not for, say, the twenty-ninth drug to come on the market to treat “erectile dysfunction,” or some such), if great care was taken to avoid the least bit of unnecessary pain in the animals, and if people would live their lives in such a manner as to justify the animals’ involuntary sacrifice on our parts. That last part clearly is not happening. Check out this article about dogs trussed up and forced to smoke 30 cigarettes a day as part of an effort to develop a “safer cigarette.” Why the Hell don’t people just stop smoking cigarettes? Or, if they won’t do that, why won’t they accept the consequences of their behavior? After all, they had a choice in the matter – the dogs don’t.

smoking beagles 

I’ve been wondering, as of late, how the people who do such research can face themselves in the mirror with a clear conscience. Then again, maybe they can’t. One of my students, who works in a veterinarian's office, told me this astounding story. She said that some of their clients are people who work in biomedical research labs, where their work involves giving cancer to rats. After their work is finished, they are supposed to kill the rats, of course, but sometimes they don’t. Sometimes they smuggle the rats out and take them home and spend thousands of dollars trying to cure them. (No, I don’t know how they decide which rats die and which are worth saving.) That strikes me as an absolutely bizarre method of expiating one’s feelings of guilt, and certainly a poor substitute for an intelligent conversation about the trade-offs inherent in this or any other human choice.
















Your tags:

TIP:

Enter the amount, and click "Tip" to submit!
Recipient's email address:
Personal message (optional):

Your email address:

Comments

Type your comment below:
The last person you want doing animal experimentation is the person who doesn't care how the animal feels. Some experiments can be justified for the common good as you state above, and others can't.

When a PETA representative debated the head veterinarian of the Animal Care and Use Committee at a state university I worked at, the PETA representative stated that if it were a choice between his child's life and those of lab animals, his kid would win. But it's hard to know which research will end up being important, so nothing is simple. What MUST be done is insure that research is performed as humanely and painlessly as possible.

I currently have a 16 year old "retired" research dog living with me. She was a blood-donor dog for research on a canine retrovirus I was studying. I refused to pass her on to what might have been a terminal project. You will find that most scientists are far from heartless.
Thanks for your comment.

You know, I passed on to my department head that little story about researchers taking the rats home and spending thousands of dollars trying to cure them, and she was astonished. She told me that rats live only a year or two in any event, and most of them end up dying from -- you guessed it -- cancer.

Go figure.
I worked with mice in research and it was heartbreaking to dissect them, especially the younger ones, but animal models are extremely important for genetic research - we can't just start injecting people to turn off genes and see what happens. It's the only way to determine the real life function of a gene. The sequence is start in cell culture, move to small animals, move to bigger animals, move to clinical trials (usually by different, specialized labs and then a pharma company). My lab actually discovered genetic mutations that make certain subpopulations more susceptible to hypertension via a particular mechanism, the first step to being able to start treatment with the right drug from the start as opposed to testing five different ones as the patient worsens and feels horrible (also opening the door to better understanding the influence of intrinsic factors and hormones on the development of hypertension). Unfortunately, the work is all hung up in publication. Sometimes the best intentions and research deserving of the exception doesn't become public knowledge - there are a dozen pitfalls that can make the use of animals "in vain" - but that doesn't mean it shouldn't be done.

There are so many regulations in place to protect the animals - most of them just eat, sleep, and breed in sterile conditions. It's strictly regulated by IRBs and researchers have lost funding and their jobs for bypassing them. The Animal Welfare Act made research very difficult, but it addressed concerns over the ethical treatment of animals.
Years ago, I was doing a study testing the efficacy of a venom extractor in removing venom from honeybee stings. We shaved a rabbit and stung it twelve times and measured the amount of venom we could remove from each sting. We had to give the rabbit a local anaesthetic and an analgesic. At the time, I thought these were overly fastidious precautions until I did some rough calculations and figured out that on a per-pound basis it was like me getting stung about a thousand times.

Thanks for your comments.